Vyvanse (Lisdexamfetamine)


What Is Vyvanse

Vyvanse (lisdexamfetamine) is used as part of a treatment program to control symptoms of attention deficit hyperactivity disorder (ADHD; more difficulty focusing, controlling actions, and remaining still or quiet than other people who are the same age) in adults and children. Vyvanse (lisdexamfetamine) is also used to treat binge eating disorder (an eating disorder characterized by periods of uncontrolled overeating). Do not use Vyvanse (lisdexamfetamine) for weight loss; use of sympathomimetic drugs for weight loss is associated with serious adverse cardiovascular events

What Does Vyvanse Do?

Vyvanse (lisdexamfetamine) is a dextroamphetamine drug precursor, a non-catecholamine sympathomimetic amine, that also functions as a central nervous system (CNS) stimulant and dopamine uptake inhibitor and is used in the treatment of attention deficit/hyperactivity disorder (ADHD). Upon administration, lisdexamphetamine is converted to dextroamphetamine through cleavage of the lysine group.

How Should Vyvanse Medication Be Used?

Vyvanse (lisdexamfetamine) comes as a capsule to be taken by mouth. Vyvanse is usually taken once a day in the morning with or without food. Take Vyvanse (lisdexamfetamine) at around the same time every day. Do not take Vyvanse (lisdexamfetamine) in the late afternoon or evening because it may cause difficulty falling asleep or staying asleep. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Vyvanse (lisdexamfetamine) exactly as directed.

Vyvanse Special Precautions

Before taking Vyvanse:

  • tell your doctor and pharmacist if you are allergic to Vyvanse (lisdexamfetamine); other stimulant medications such as amphetamine (in Adderall), benzphetamine (Didrex), dextroamphetamine (in Adderall, Dexedrine, Dextrostat), methamphetamine (Desoxyn); any other medications, or any of the ingredients in Vyvanse (lisdexamfetamine) capsules. Ask your doctor or pharmacist or check the manufacturer’s information for a list of the ingredients.
  • tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking one of these medications during the past 2 weeks. Your doctor will probably tell you not to take Vyvanse (lisdexamfetamine) until at least 14 days have passed since you last took an MAO inhibitor.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: acetazolamide (Diamox), ascorbic acid (Vitamin C), other medications for ADHD, sodium bicarbonate (Arm and Hammer Baking Soda, Soda Mint), and sodium phosphate (OsmoPrep, Visicol). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with Vyvanse (lisdexamfetamine), so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • tell your doctor if anyone in your family has or has ever had an irregular heartbeat or has died suddenly. Also tell your doctor if you have recently had a heart attack and if you have or have ever had a heart defect, high blood pressure, an irregular heartbeat, hardening of the arteries, or other heart problems. Your doctor will examine you to see if your heart and blood vessels are healthy before you start taking Vyvanse (lisdexamfetamine) and will check your heart and blood pressure regularly during your treatment with Vyvanse (lisdexamfetamine). Your doctor will probably tell you not to take Vyvanse (lisdexamfetamine) if you have a heart condition or if there is a high risk that you may develop a heart condition.
  • Vyvanse Vs Adderall

    Adderall contains a combination of amphetamine and dextroamphetamine. Amphetamine and dextroamphetamine are central nervous system stimulants that affect chemicals in the brain and nerves that contribute to hyperactivity and impulse control.

    Adderall is used to treat narcolepsy and attention deficit hyperactivity disorder (ADHD).

  • Amphetamine is reported to be oxidized at the 4 position of the benzene ring to form 4-hydroxyamphetamine, or on the side chain α or β carbons to form alpha-hydroxy-amphetamine or norephedrine, respectively. Norephedrine and 4-hydroxy-amphetamine are both active and each is subsequently oxidized to form 4-hydroxy-norephedrine. Alpha-hydroxy-amphetamine undergoes deamination to form phenylacetone, which ultimately forms benzoic acid and its glucuronide and the glycine conjugate hippuric acid. Although the enzymes involved in amphetamine metabolism have not been clearly defined, CYP2D6 is known to be involved with formation of 4-hydroxy-amphetamine. Since CYP2D6 is genetically polymorphic, population variations in amphetamine metabolism are a possibility.Amphetamine is known to inhibit monoamine oxidase, whereas the ability of amphetamine and its metabolites to inhibit various P450 isozymes and other enzymes has not been adequately elucidated. In vitro experiments with human microsomes indicate minor inhibition of CYP2D6 by amphetamine and minor inhibition of CYP1A2, 2D6, and 3A4 by one or more metabolites. However, due to the probability of auto-inhibition and the lack of information on the concentration of these metabolites relative to in vivo concentrations, no predications regarding the potential for amphetamine or its metabolites to inhibit the metabolism of other drugs by CYP isozymes in vivo can be made.

    Adderall contraindications

    Advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to the sympathomimetic amines, glaucoma.

    Agitated states.

    Patients with a history of drug abuse.

    During or within 14 days following the administration of monoamine oxidase inhibitors (hypertensive crises may result).

    Adderall important information

    Adderall may be habit-forming, and this medicine is a drug of abuse. Tell your doctor if you have had problems with drug or alcohol abuse.

    Stimulants have caused stroke, heart attack, and sudden death in people with high blood pressure, heart disease, or a heart defect.



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